MKNK2 Gene Summary [Human]
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MKNK2 |
| Official Name | MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111] |
| Ensembl ID | ENSG00000099875 |
| Bio databases IDs | |
| Aliases | MAPK interacting serine/threonine kinase 2, Putative map kinase interacting kinase |
| Synonyms | 2010016G11Rik, DKFZP434N0211, GPRK7, MAP kinase-interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2, Mknk2a, MNK2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MKNK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- MAPK binding site
- ATP binding
- protein binding
- Protein kinase domain
- basic domain
Pathways
Biological processes and signaling networks where the MKNK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- cleft lip
- carpal tunnel syndrome
- tumorigenesis
role in cell
- activation in
- expression in
- growth
- phosphorylation in
- colony formation
- response by
- signal transduction in
- hematopoiesis
- suppression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MKNK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- hemopoiesis
- cellular response to arsenic-containing substance
- protein autophosphorylation
- cell surface receptor signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- metal ion binding
- calmodulin-dependent protein kinase activity
- protein serine/threonine kinase activity
- calcium-dependent protein serine/threonine kinase activity