Scn7a Gene Summary [Rat]
Enables osmolarity-sensing monoatomic cation channel activity. Involved in sodium ion homeostasis. Predicted to be located in glial cell projection. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in plasma membrane. Biomarker of brain infarction. Orthologous to human SCN7A (sodium voltage-gated channel alpha subunit 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn7a |
| Official Name | sodium voltage-gated channel alpha subunit 7 [Source:RGD Symbol;Acc:61922] |
| Ensembl ID | ENSRNOG00000029342 |
| Bio databases IDs | |
| Aliases | sodium voltage-gated channel alpha subunit 7 |
| Synonyms | 1110034K09Rik, Na-G, Nav2, Nav2.1, Nav2.2, Nav2.3, Nax, SCL-11, SCN6A, sodium channel, voltage-gated, type VII, alpha, sodium channel, voltage-gated, type VII, α, sodium voltage-gated channel alpha subunit 7, sodium voltage-gated channel α subunit 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scn7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium ion transport-associated
- osmosensor
- sodium channel
- Ion transport protein
- channel/pore class transporter
- inorganic uptake permease
- protein binding
- ion channel
- cation channel
Pathways
Biological processes and signaling networks where the Scn7a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Huntington disease
- fatigue
- idiopathic scoliosis
- major depression
- Tourette syndrome
- amyotrophic lateral sclerosis
- colorectal cancer
- uterine leiomyoma
- leiomyomatosis
regulates
- FOS
- Na+
role in cell
- transmembrane potential
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- nodes of Ranvier
- glial cell projections
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scn7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- cellular homeostasis
- response to bacterium
- osmosensory signaling pathway
- sodium ion homeostasis
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- voltage-gated sodium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium channel activity
- ion channel binding
- voltage-gated sodium channel activity