Erbin Gene Summary [Rat]
Predicted to enable protein kinase binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; protein localization to membrane; and regulation of gene expression. Predicted to act upstream of or within protein targeting. Is active in glutamatergic synapse; neuromuscular junction; and postsynaptic specialization. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Erbin |
| Official Name | erbb2 interacting protein [Source:RGD Symbol;Acc:1562952] |
| Ensembl ID | ENSRNOG00000047137 |
| Bio databases IDs | |
| Aliases | erbb2 interacting protein |
| Synonyms | 1700028E05Rik, Erbb2i, Erbb2 interacting protein, ERBB2IP, HEL-S-78, LAP2, LOC100361629, mKIAA1225, RGD1562952 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Erbin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- smad binding domain
- Leucine rich repeat
- canonical PDZ domain
- Neu/ErbB-2 receptor binding
- protein binding
- receptor binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Pathways
Biological processes and signaling networks where the Erbin gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- tumorigenesis
- idiopathic scoliosis
- endometriosis
- hypomyelination
- mechanical hypersensitivity
- decreased nerve conduction velocity
- squamous-cell carcinoma
- squamous cell cancer
- cardiac hypertrophy
role in cell
- generation in
- phosphorylation in
- proliferation
- quantity
- differentiation
- senescence
- abnormal morphology
- response by
- autophagy by
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- membrane fraction
- pH resistant lipid raft fraction
- glutaminergic synapse
- cell junction
- organelle
- postsynaptic region
- Nucleus
- Plasma Membrane
- hemidesmosomes
- cell-cell contacts
- basolateral membrane
- lateral plasma membrane
- nuclear speckles
- neuromuscular junctions
- paranodes
- synaptosomes
- sarcolemma
- dendrites
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Erbin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
- response to muramyl dipeptide
- signal transduction
- epidermal growth factor receptor signaling pathway
- intermediate filament cytoskeleton organization
- cell adhesion
- protein targeting
- integrin-mediated signaling pathway
- establishment or maintenance of epithelial cell apical/basal polarity
- basal protein localization
- cellular response to tumor necrosis factor
- response to lipopolysaccharide
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- negative regulation of monocyte chemotactic protein-1 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- basal plasma membrane
- basement membrane
- nuclear membrane
- cytoplasm
- nuclear speck
- cell junction
- neuromuscular junction
- hemidesmosome
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ErbB-2 class receptor binding
- structural constituent of cytoskeleton
- receptor binding