Slc8a3 Gene Summary [Rat]
Enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Involved in cellular response to cAMP; metal ion transport; and telencephalon development. Acts upstream of or within intracellular calcium ion homeostasis. Located in several cellular components, including dendritic spine; neuronal cell body; and sarcolemma. Is active in postsynaptic membrane. Biomarker of brain ischemia and status epilepticus. Orthologous to human SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc8a3 |
| Official Name | solute carrier family 8 member A3 [Source:RGD Symbol;Acc:620197] |
| Ensembl ID | ENSRNOG00000029871 |
| Bio databases IDs | |
| Aliases | solute carrier family 8 member A3 |
| Synonyms | NCX3, solute carrier family 8 member A3, solute carrier family 8 (sodium/calcium exchanger), member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc8a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium:sodium antiporter
- calcium:cation antiporter
- sodium/calcium exchanger 1
- Sodium/calcium exchanger protein
- C-terminal extension of sodium/calcium exchanger domain
- protein binding
- Calx-beta domain
- Domains in Na-Ca exchangers and integrin-beta4
- transporter
Pathways
Biological processes and signaling networks where the Slc8a3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- neurodegeneration
- fatigue
- pervasive developmental disorder
- cystic fibrosis
- dementia
regulates
- Ca2+
- Na+
- SLC8A3
- ion channel
- ion
- DNA endogenous promoter
- metal ion
role in cell
- differentiation
- response by
- homeostasis in
- transport in
- synaptic transmission
- necrosis
- organization
- survival
- transactivation in
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- perinuclear region
- cellular membrane
- centrosome
- microtubules
- cytosol
- sarcoplasm
- endoplasmic reticulum membrane
- postsynaptic membrane
- mitochondrial outer membrane
- nucleoplasm
- dendritic spines
- neuromuscular junctions
- synapse
- sarcolemma
- cellular protrusions
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc8a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- synapse organization
- cell communication
- myelination
- learning
- memory
- mitochondrial calcium ion transport
- hemopoietic progenitor cell differentiation
- cellular calcium ion homeostasis
- learning or memory
- ion transport
- regulation of skeletal muscle contraction
- mitochondrial calcium ion homeostasis
- calcium ion transmembrane transport
- long-term synaptic potentiation
- sodium ion transmembrane transport
- cellular response to hypoxia
- negative regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- sarcoplasm
- neuronal cell body
- synapse
- perikaryon
- mitochondrial outer membrane
- plasma membrane
- axon terminus
- endoplasmic reticulum membrane
- dendrite
- perinuclear region of cytoplasm
- anchoring junction
- sarcolemma
- dendritic spine
- neuromuscular junction
- axon
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- metal ion binding
- calcium:sodium antiporter activity