Cabin1 Gene Summary [Rat]
Enables protein domain specific binding activity and protein phosphatase 2B binding activity. Involved in negative regulation of apoptotic process and response to activity. Predicted to be located in aggresome; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cabin1 |
| Official Name | calcineurin binding protein 1 [Source:RGD Symbol;Acc:620263] |
| Ensembl ID | ENSRNOG00000001237 |
| Bio databases IDs | |
| Aliases | calcineurin binding protein 1 |
| Synonyms | A330070M20Rik, CAIN, calcineurin binding protein 1, KB-318B8.7, LOC103689948, PPP3IN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cabin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- protein phosphatase 2B binding
- inhibitory domain
- coiled-coil domain
- protein domain specific binding
- protein binding
- calcineurin-binding domain
- tetratricopeptide repeat
- proline rich domain
- calcineurin-inhibitory domain
- MEF2 binding
Pathways
Biological processes and signaling networks where the Cabin1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
role in cell
- cell death
- apoptosis
- hypertrophy
- development
- activation
- assembly
- exocytosis
- heterochromatinization in
- heterochromatinization
- receptor-mediated endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- Cytoplasm
- cytosol
- nucleoplasm
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cabin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- nucleosome binding