Krt4 Gene Summary [Rat]
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization; keratinization; and negative regulation of epithelial cell proliferation. Predicted to be located in cell surface and intermediate filament cytoskeleton. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in white sponge nevus 1. Orthologous to human KRT4 (keratin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt4 |
| Official Name | keratin 4 [Source:RGD Symbol;Acc:1359272] |
| Ensembl ID | ENSRNOG00000032332 |
| Bio databases IDs | |
| Aliases | keratin 4 |
| Synonyms | CK-4, CYK4, K4, Kb4, keratin 4, KRT2-4, WSN1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
- Keratin type II head
Pathways
Biological processes and signaling networks where the Krt4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- cell surface
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- cytoskeleton organization
- negative regulation of epithelial cell proliferation
- keratinization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- keratin filament
- intermediate filament cytoskeleton
- cytosol
- intermediate filament
- cell surface
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding