Nsmaf Gene Summary [Rat]
Enables sphingomyelin phosphodiesterase activator activity. Involved in positive regulation of apoptotic process. Orthologous to human NSMAF (neutral sphingomyelinase activation associated factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsmaf |
| Official Name | neutral sphingomyelinase activation associated factor [Source:RGD Symbol;Acc:727868] |
| Ensembl ID | ENSRNOG00000010234 |
| Bio databases IDs | |
| Aliases | neutral sphingomyelinase activation associated factor |
| Synonyms | C630007J05, FAN, GRAMD5, neutral sphingomyelinase activation associated factor, neutral sphingomyelinase (N-SMase) activation associated factor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nsmaf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- WD40 repeats
- sphingomyelin phosphodiesterase activator
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
- Pleckstrin homology-like domain
- Beach
Pathways
Biological processes and signaling networks where the Nsmaf gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- early endosomes
- perinuclear vesicles
- sorting endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nsmaf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cellular amide metabolic process
- tumor necrosis factor-mediated signaling pathway
- signal transduction
- positive regulation of apoptotic process
- ceramide metabolic process
- positive regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- sphingomyelin phosphodiesterase activator activity