Duox1 Gene Summary [Rat]
Predicted to enable superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in several processes, including hydrogen peroxide biosynthetic process; response to cAMP; and superoxide anion generation. Predicted to act upstream of or within reactive oxygen species metabolic process. Predicted to be located in cell leading edge; cell surface; and endoplasmic reticulum. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Orthologous to human DUOX1 (dual oxidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Duox1 |
| Official Name | dual oxidase 1 [Source:RGD Symbol;Acc:628760] |
| Ensembl ID | ENSRNOG00000033348 |
| Bio databases IDs | |
| Aliases | dual oxidase 1 |
| Synonyms | 9930101G15Rik, dual oxidase 1, Duox2, LNOX1, LNOX2, NOXEF1, NOXEF2, P138-TOX, THOX1, THOX2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Duox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- EF-hand, calcium binding motif
- EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
- EF-hand domain pair
- Cytochrome_b_N
- EFh
- Animal haem peroxidase
- enzyme
- Animal heme peroxidases and related proteins
- protein binding
- proline rich domain
- The penta-EF hand (PEF) family
- EF-hand domain
- EF hand
- NADPH oxidase
- Oxidoreductase NAD-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- congenital hypothyroidism
- lung adenocarcinoma
- hypothyroidism
- radiation-induced papillary thyroid cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- airway hyperresponsiveness
- epithelial thyroid cancer
role in cell
- apoptosis
- phosphorylation in
- expression in
- production in
- damage in
- generation in
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular membranes
- cellular membrane
- Endoplasmic Reticulum
- apical membrane
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Duox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of wound healing
- thyroid hormone generation
- response to cAMP
- superoxide anion generation
- defense response
- cuticle development
- hormone biosynthetic process
- hydrogen peroxide catabolic process
- response to oxidative stress
- cytokine-mediated signaling pathway
- hydrogen peroxide biosynthetic process
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- NADPH oxidase complex
- cell leading edge
- endoplasmic reticulum
- plasma membrane
- apical plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- NADP binding
- protein binding
- calcium ion binding
- NAD(P)H oxidase activity
- superoxide-generating NADPH oxidase activity
- heme binding