Bud23 Gene Summary [Rat]
Predicted to enable protein heterodimerization activity and rRNA (guanine) methyltransferase activity. Predicted to be involved in positive regulation of rRNA processing and rRNA (guanine-N7)-methylation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bud23 |
| Official Name | BUD23, rRNA methyltransferase and ribosome maturation factor [Source:RGD Symbol;Acc:1589742] |
| Ensembl ID | ENSRNOG00000033700 |
| Bio databases IDs | |
| Aliases | BUD23, rRNA methyltransferase and ribosome maturation factor |
| Synonyms | 1110003N24Rik, BUD23 rRNA methyltransferase and ribosome maturation factor, BUD23, rRNA methyltransferase and ribosome maturation factor, HASJ4442, HUSSY-3, LOC360830, MERM1, PP3381, WBMT, WBSCR22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bud23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
- Methyltransferase involved in Williams-Beuren syndrome
- protein heterodimerization
- rRNA (guanine) methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection
- pulmonary fibrosis
- hyperplasia
- pulmonary tuberculosis
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung cancer
- liver cancer
role in cell
- expression in
- cell viability
- apoptosis
- processing in
- recruitment in
- trimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- extranuclear space
- Cytoplasm
- perinuclear region
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bud23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of rRNA processing
- rRNA (guanine-N7)-methylation
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- protein heterodimerization activity
- methyltransferase activity
- rRNA (guanine) methyltransferase activity