Mir16 Gene Summary [Rat]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | Mir16 |
| Official Name | microRNA 16 [Source:RGD Symbol;Acc:7488974] |
| Ensembl ID | ENSRNOG00000035504 |
| Bio databases IDs | |
| Aliases | microRNA 16 |
| Synonyms | hsa-miR-15, hsa-miR-15a, hsa-miR-15b, hsa-miR-15b MM1, HSA-MIR-16, hsa-mir-16-1, hsa-mir-16-2, hsa-miR-195, microRNA 15a, microRNA 15b, microRNA 16, microRNA 16-1, microRNA 16-2, microRNA 195, microRNA 195a, microRNA mir-15a, MIR15/16/195, miR-15/16 family, MIR15A, MIR15B, miR-15b-prec, MIR-16, MIR16-1, MIR16-2, mir-16-3, MIR195, MIR195 3p, Mir195a, MIRN15A, MIRN15B, MIRN16, MIRN16-1, MIRN16-2, MIRN195, miRNA15A, miRNA16-1, miRNA195, mmu-miR-15a, mmu-miR-15b, mmu-miR-16, mmu-mir-16-1, mmu-mir-16-2, mmu-miR-195, mmu-mir-195a, Pri-miRNA-16, rno-mir-15a, rno-miR-15b, rno-miR-16, rno-miR-195 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mir16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- neoplasia
- prostate cancer
- adenoma formation
- epithelial neoplasia
- epithelial cancer
- cancer
- dementia
- schizophrenia
- soft tissue sarcoma cancer
regulated by
- lipopolysaccharide
- neutrophils
- sodium chloride
- hydrogen peroxide
- D-glucose
- etoposide
- PLCE1
- E2F1
- BMS-754807
- MCF7 cells
role in cell
- apoptosis
- proliferation
- disassembly
- expression in
- differentiation
- survival
- growth
- activation
- response
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mir16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of cell proliferation
- negative regulation of inflammatory response
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of cyclin-dependent protein kinase activity
- negative regulation of cell migration involved in sprouting angiogenesis
- negative regulation of peptidyl-threonine phosphorylation
- cellular response to glucose stimulus
- positive regulation of apoptotic process
- negative regulation of G1/S transition of mitotic cell cycle
- positive regulation of endothelial cell apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding