Mir140 Gene Summary [Rat]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | Mir140 |
| Official Name | microRNA 140 [Source:RGD Symbol;Acc:2325351] |
| Ensembl ID | ENSRNOG00000035609 |
| Bio databases IDs | |
| Aliases | microRNA 140 |
| Synonyms | HSA-MIR-140, microRNA 140, MIR140A, MIRN140, miRNA140, mmu-miR-140, rno-miR-140, SEDN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mir140 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the Mir140 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- Nishimura type spondyloepiphyseal dysplasia
- bipolar disorder
- Huntington disease
- ischemic cardiomyopathy
- osteoarthritis
- breast cancer
role in cell
- apoptosis
- proliferation
- growth
- expression in
- migration
- number
- differentiation
- function
- survival
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mir140 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of SMAD protein import into nucleus
- negative regulation of chemokine production
- negative regulation of NF-kappaB transcription factor activity
- gene silencing by miRNA
- negative regulation of toll-like receptor 4 signaling pathway
- negative regulation of cytokine production involved in inflammatory response
- defense response to bacterium
- negative regulation of osteoblast differentiation
- negative regulation of interleukin-6 production
- positive regulation of BMP signaling pathway
- negative regulation of gene expression
- cellular response to lipopolysaccharide
- positive regulation of gene expression
- cellular response to hypoxia
- mRNA cleavage involved in gene silencing by miRNA
- negative regulation of tumor necrosis factor production
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding