Wnt11 Gene Summary [Rat]
Predicted to enable cytokine activity; frizzled binding activity; and protein kinase activator activity. Involved in cell differentiation and response to nutrient levels. Predicted to be located in cytoplasm; extracellular matrix; and extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt11 |
| Official Name | Wnt family member 11 [Source:RGD Symbol;Acc:621463] |
| Ensembl ID | ENSRNOG00000015982 |
| Bio databases IDs | |
| Aliases | Wnt family member 11 |
| Synonyms | HWNT11, wingless-type MMTV integration site family, member 11, Wnt family member 11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnt11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- Wnt
- wnt family
- GTPase activator
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
- hypoplasia
- developmental delay
- osteoarthritis
- colon adenocarcinoma
- colon epithelial cancer
- squamous cell lung cancer
- rheumatoid arthritis
- lung adenocarcinoma
role in cell
- expression in
- migration
- aggregation
- phosphorylation in
- apoptosis
- differentiation
- activation in
- proliferation
- maturation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnt11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- protein localization at cell surface
- somite development
- positive regulation of GTPase activity
- planar cell polarity pathway involved in axis elongation
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- neuron differentiation
- cloacal septation
- Wnt receptor signaling pathway, calcium modulating pathway
- artery morphogenesis
- ureteric bud morphogenesis
- primary heart field specification
- secondary heart field specification
- notochord morphogenesis
- positive regulation of stress fiber assembly
- negative regulation of stem cell proliferation
- positive regulation of transforming growth factor beta2 production
- mesonephric duct development
- tight junction assembly
- epithelial to mesenchymal transition
- response to nutrient levels
- mesenchymal cell proliferation
- negative regulation of cell migration
- negative regulation of cartilage development
- positive regulation of protein kinase C signaling cascade
- outflow tract morphogenesis
- negative regulation of fibroblast growth factor production
- protein phosphorylation
- convergent extension involved in axis elongation
- paraxial mesoderm formation
- maintenance of epithelial cell apical/basal polarity
- negative regulation of mesenchymal cell proliferation
- stem cell proliferation
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- adrenal gland development
- neuroendocrine cell differentiation
- bone mineralization
- signal transduction
- atrial septum development
- embryonic skeletal system development
- planar cell polarity pathway involved in gastrula mediolateral intercalation
- ventricular septum morphogenesis
- negative regulation of canonical Wnt receptor signaling pathway
- cellular response to mechanical stimulus
- cellular response to retinoic acid
- cell fate commitment
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- protein kinase activator activity
- GTPase activator activity
- cytokine activity