Mir23a Gene Summary [Rat]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | Mir23a |
| Official Name | microRNA 23a [Source:RGD Symbol;Acc:2325395] |
| Ensembl ID | ENSRNOG00000035644 |
| Bio databases IDs | |
| Aliases | microRNA 23a |
| Synonyms | hsa-miR-23a, hsa-miR-23a/b, hsa-miR-23b, microRNA 23a, microRNA 23b, MIR23A, MIR23B, MIRN23A, MIRN23B, miRNA23A, miRNA23B, mmu-miR-23a, mmu-miR-23b, pre-miRNA miR-23, rno-miR-23a, rno-miR-23b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mir23a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the Mir23a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- albuminuria
- lung cancer
- epithelial cancer
- renal impairment
- metastasis
- ischemic cardiomyopathy
- colorectal cancer
- colorectal carcinomagenesis
- primary melanoma
role in cell
- apoptosis
- growth
- production in
- expression in
- hypertrophy
- phosphorylation in
- proliferation
- activation in
- synthesis in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mir23a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of SMAD protein import into nucleus
- gene silencing by miRNA
- positive regulation of gene expression
- negative regulation of cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of apoptotic process
- cellular response to vascular endothelial growth factor stimulus
- cell growth involved in cardiac muscle cell development
- positive regulation of cell migration involved in sprouting angiogenesis
- mRNA cleavage involved in gene silencing by miRNA
- negative regulation of vascular permeability
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding