Agk Gene Summary [Rat]
Predicted to enable acylglycerol kinase activity and lipid kinase activity. Predicted to be involved in ceramide biosynthetic process; protein insertion into mitochondrial inner membrane; and sphingosine biosynthetic process. Predicted to act upstream of or within lipid phosphorylation. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in membrane and mitochondrion. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agk |
| Official Name | acylglycerol kinase [Source:RGD Symbol;Acc:1562046] |
| Ensembl ID | ENSRNOG00000011509 |
| Bio databases IDs | |
| Aliases | acylglycerol kinase |
| Synonyms | 2610037M15Rik, 6720408I04RIK, acylglycerol kinase, CATC5, CTRCT38, FLJ10842, MTDPS10, MULK, RGD1562046 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Agk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- lipid kinase
- diacylglycerol kinase
- acylglycerol kinase
- Diacylglycerol kinase catalytic domain
- Acylglycerol kinase C-terminal
- protein binding
- ceramide kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
- Sengers syndrome
- hereditary disorder
- psoriasis
- epithelial ovarian cancer
- organismal death
- liver cancer
- androgenic alopecia
- fibrosis
role in cell
- proliferation
- apoptosis
- number
- migration
- phosphorylation in
- expression in
- accumulation in
- quantity
- production in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- intracellular membranes
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Agk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerolipid metabolic process
- ceramide biosynthetic process
- protein import into mitochondrial inner membrane
- lipid phosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial membrane
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- mitochondrial outer membrane
- mitochondrial inner membrane protein insertion complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- acylglycerol kinase activity
- diacylglycerol kinase activity
- ceramide kinase activity