Uhrf1 Gene Summary [Rat]
Predicted to enable several functions, including DNA binding activity; methylated histone binding activity; and zinc ion binding activity. Involved in response to peptide hormone. Predicted to be located in chromosome and nuclear lumen. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uhrf1 |
| Official Name | ubiquitin-like with PHD and ring finger domains 1 [Source:RGD Symbol;Acc:1595855] |
| Ensembl ID | ENSRNOG00000048411 |
| Bio databases IDs | |
| Aliases | ubiquitin-like with PHD and ring finger domains 1 |
| Synonyms | Ac2-121, hNP95, hUHRF1, huNp95, ICBP90, NP95, RNF106, TDRD22, ubiquitin-like, containing PHD and RING finger domains, 1, ubiquitin-like with PHD and ring finger domains 1, UHRG1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uhrf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- protein binding activity, bridging
- enzyme
- Tandem tudor domain within UHRF1
- ubiquitin-like domain
- identical protein binding
- Ubiquitin family
- zinc ion binding
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- SAD/SRA domain
- Ubiquitin homologues
- zinc-RING finger domain
- histone binding
- nucleic acid binding
- ubiquitin protein ligase activity
- nuclear localization sequence
- Ring finger domain
- protein binding
- sequence-specific DNA binding
- RING-type zinc-finger
- double-stranded DNA binding
- Ubl1_cv_Nsp3_N-like
- methyl-CpG binding
- ubiquitin-protein transferase activity
- PHD finger superfamily
- Tudor domain superfamily
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Uhrf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- metabolic syndrome X
- gastric cancer
- abdominal cancer
- gastroesophageal cancer
- gastrointestinal tract cancer
- gastrointestinal neoplasia
- cancer
- digestive system cancer
- non-insulin-dependent diabetes mellitus
role in cell
- binding in
- expression in
- activation in
- migration
- cell survival
- exchange
- proliferation
- survival
- quantity
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear matrix fraction
- heterochromatin
- cytosol
- nucleoplasm
- nuclear matrix
- DNA replication foci
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uhrf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
- double-strand break repair via homologous recombination
- hypermethylation of CpG island
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- regulation of gene expression, epigenetic
- ubiquitin-dependent protein catabolic process
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of protein metabolic process
- heterochromatin assembly
- reciprocal DNA recombination
- regulation of epithelial cell proliferation
- spindle assembly involved in mitosis
- protein ubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- heterochromatin
- euchromatin
- spindle
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ubiquitin-protein ligase activity
- zinc ion binding
- identical protein binding
- protein binding
- histone binding
- methylated histone residue binding
- core promoter proximal region sequence-specific DNA binding
- methyl-CpG binding