Slc10a2 Gene Summary [Rat]
Enables bile acid:sodium symporter activity. Involved in bile acid and bile salt transport. Located in apical plasma membrane. Part of proteasome complex. Human ortholog(s) of this gene implicated in intestinal disease. Orthologous to human SLC10A2 (solute carrier family 10 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc10a2 |
| Official Name | solute carrier family 10 member 2 [Source:RGD Symbol;Acc:3682] |
| Ensembl ID | ENSRNOG00000037753 |
| Bio databases IDs | |
| Aliases | solute carrier family 10 member 2 |
| Synonyms | 9130221J18Rik, ABAT, ASBT, IBAT, ISBAT, ISBT, NTCP2, PBAM, PBAM1, solute carrier family 10 member 2, solute carrier family 10, member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc10a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- bile acid:sodium symporter
- bile acid transporter
- protein binding
- Sodium Bile acid symporter family
- cytosolic tail domain
- Predicted Na+-dependent transporter YfeH [General function prediction only]
- transporter
Pathways
Biological processes and signaling networks where the Slc10a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- Crohn disease
- Alagille syndrome
- primary bile acid malabsorption type 1
- progressive intrahepatic cholestasis
- cholelithiasis
- biliary atresia
- primary biliary cirrhosis
- hyperlipoproteinemia type IV
- progressive familial intrahepatic cholestasis type 2
regulates
- cholesterol
- lipid
- Na+
- ALP
- cholesterol ester
- NR1H4
- glycocholic acid
- taurocholic acid
- bilirubin
- bile salt
role in cell
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- intracellular space
- perinuclear region
- cellular membrane
- cytoplasmic particles
- apical cell surfaces
- apical membrane
- basolateral membrane
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc10a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- response to bacterium
- transmembrane transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- microvillus
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid:sodium symporter activity
- protein binding