Atp6v0c Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of autophagic cell death and positive regulation of ERK1 and ERK2 cascade. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0c |
| Official Name | ATPase H+ transporting V0 subunit C [Source:RGD Symbol;Acc:621394] |
| Ensembl ID | ENSRNOG00000006542 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V0 subunit C |
| Synonyms | 16K, ATP6C, Atp6c2, ATP6L, ATPase, H+ transporting, lysosomal V0 subunit C, ATPase H+ transporting V0 subunit C, ATPL, Atpl-rs1, EPEO3, PL16, Vacuolar H+ ATPase Proton Channel Subunit, VATL, V-ATPase C subunit, V-ATPase V0-c, Vma3, VPPC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v0c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP synthase subunit C
- ubiquitin protein ligase binding
- PRK13469
- transmembrane domain
- ATP synthase, membrane-bound Fo/Vo/Ao complexes, subunit c
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- H+-exporting ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp6v0c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- early-onset epilepsy with developmental delay 3
- early-onset epilepsy without developmental delay type 3
- early-onset epilepsy with or without developmental delay 3
- childhood onset epilepsy syndrome
role in cell
- expression in
- replication in
- binding in
- growth
- invasion
- formation
- morphology
- Clathrin mediated endocytosis by
- communication by
- endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- synaptic vesicle membrane
- perinuclear region
- cellular membrane
- Plasma Membrane
- secretory granule membrane
- cytoplasmic particles
- tertiary granule membrane
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- ruffled borders
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v0c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular pH reduction
- endosomal lumen acidification
- lysosomal lumen acidification
- regulation of macroautophagy
- vacuolar acidification
- positive regulation of Wnt receptor signaling pathway
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- proton-transporting V-type ATPase complex
- Golgi membrane
- lysosomal membrane
- plasma membrane
- vacuolar proton-transporting V-type ATPase, V0 domain
- extracellular vesicular exosome
- focal adhesion
- membrane
- phagocytic vesicle membrane
- endosome membrane
- synaptic vesicle membrane
- azurophil granule membrane
- tertiary granule membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- proton-transporting ATPase activity, rotational mechanism
- hydrogen ion transporting ATP synthase activity, rotational mechanism