Cysltr1 Gene Summary [Rat]
Enables leukotriene receptor activity. Involved in several processes, including cellular response to hypoxia; positive regulation of glial cell proliferation; and positive regulation of vasoconstriction. Predicted to be active in plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cysltr1 |
| Official Name | cysteinyl leukotriene receptor 1 [Source:RGD Symbol;Acc:619796] |
| Ensembl ID | ENSRNOG00000037845 |
| Bio databases IDs | |
| Aliases | cysteinyl leukotriene receptor 1 |
| Synonyms | CYSLT1, CYSLT1R, CYSLTR, cysteinyl leukotriene receptor 1, HMTMF81 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cysltr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- leukotriene receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Cysltr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- perennial allergic rhinitis
- allergic rhinitis
- seasonal allergic rhinitis
- allergic rhinoconjunctivitis
- non-insulin-dependent diabetes mellitus
- insulin-dependent diabetes mellitus
- COVID-19
- dengue fever
- whooping cough
role in cell
- proliferation
- apoptosis
- number
- quantity
- expression in
- differentiation
- activation
- function
- mitogenesis
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- membrane fraction
- cell surface
- cell borders
- cellular membrane
- Nucleus
- basolateral membrane
- outer nuclear membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cysltr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of glial cell proliferation
- positive regulation of vasoconstriction
- cell surface receptor signaling pathway
- respiratory gaseous exchange
- defense response
- positive regulation of angiogenesis
- elevation of cytosolic calcium ion concentration
- chemotaxis
- neuropeptide signaling pathway
- inflammatory response to antigenic stimulus
- calcium ion transport
- establishment of localization in cell
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- cysteinyl leukotriene receptor activity
- leukotriene receptor activity
- G-protein coupled peptide receptor activity