icon_0328_cc_gen_hmr_bacteria-s

PPAR Signaling

The peroxisome proliferator-activated receptor (PPAR) family consists of PPARα, PPARδ, and PPARγ. They act as ligand activated transcriptional regulators. Their ligands include n-3 and n-6 unsaturated fatty acids and their eicosanoid products which makes the PPARs closely linked to intracellular lipid levels. As a consequence they often regulate the expression of genes involved in lipid metabolism.PPARα and -δ are found in a complex with hsp90/hsp90-XAP2 which maintain PPAR in a repressed state...

PPAR Signaling

Pathway Summary

The peroxisome proliferator-activated receptor (PPAR) family consists of PPARα, PPARδ, and PPARγ. They act as ligand activated transcriptional regulators. Their ligands include n-3 and n-6 unsaturated fatty acids and their eicosanoid products which makes the PPARs closely linked to intracellular lipid levels. As a consequence they often regulate the expression of genes involved in lipid metabolism.PPARα and -δ are found in a complex with hsp90/hsp90-XAP2 which maintain PPAR in a repressed state. These proteins dissociate upon binding of ligand to receptor. PPARα, -γ and -δ form heterodimeric complexes with the retinoid X receptor (RXR), bind to PPRE and induce genes that affect fatty acid metabolism, peroxisome proliferation,colon and hepatocarcinogenesis.PPAR function is supressed by cytokines, growth factors and insulin. For example, IL-1 and TNF-alpha suppress PPAR-γ function through NF-κB activated by the TAK1/TAB1/NIK cascade. PPARγ can be inhibited via the ERK pathway in response to growth factors. COUP-TF strongly antagonizes the action of PPARα. Thus PPARs regulate metabolic pathways.

PPAR Signaling Genes list

Explore Genes related to PPAR Signaling

Products related to PPAR Signaling

Explore products related to PPAR Signaling
GeneGlobe ID: PAHS-149Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human PPAR Targets
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: UPHS-056Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Nuclear Receptors & Coregulators
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-149Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human PPAR Targets
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-149Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human PPAR Targets
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-056Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Nuclear Receptors & Coregulators
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-056Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Nuclear Receptors & Coregulators
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.