Dnase1l2 Gene Summary [Rat]
Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to act upstream of or within corneocyte development and hair follicle development. Predicted to be active in nucleus. Orthologous to human DNASE1L2 (deoxyribonuclease 1 like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnase1l2 |
| Official Name | deoxyribonuclease 1 like 2 [Source:RGD Symbol;Acc:1583566] |
| Ensembl ID | ENSRNOG00000042352 |
| Bio databases IDs | |
| Aliases | deoxyribonuclease 1 like 2 |
| Synonyms | 4733401H14Rik, deoxyribonuclease 1-like 2, DNAS1L2, LOC100364462, LOC681124 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnase1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- calcium ion binding
- Endonuclease/Exonuclease/phosphatase family
- enzyme
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnase1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- corneocyte development
- DNA catabolic process
- hair follicle development
- DNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- DNA binding
- deoxyribonuclease activity
- calcium ion binding
- deoxyribonuclease I activity