Dnase1l2 Gene Summary [Mouse]
Predicted to enable DNA binding activity and deoxyribonuclease I activity. Acts upstream of or within DNA catabolic process; corneocyte development; and hair follicle development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in nucleus. Is expressed in several structures, including Harderian gland; alimentary system; brain; genitourinary system; and hemolymphoid system. Orthologous to human DNASE1L2 (deoxyribonuclease 1 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dnase1l2 |
| Official Name | deoxyribonuclease 1-like 2 [Source:MGI Symbol;Acc:MGI:1913955] |
| Ensembl ID | ENSMUSG00000024136 |
| Bio databases IDs | |
| Aliases | deoxyribonuclease 1-like 2 |
| Synonyms | 4733401H14Rik, deoxyribonuclease 1-like 2, DNAS1L2, LOC100364462, LOC681124 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnase1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- calcium ion binding
- Endonuclease/Exonuclease/phosphatase family
- enzyme
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- abnormal auditory brainstem response
- abnormal autopod morphology
- abnormal bone structure
- abnormal coat/ hair morphology
- abnormal coat/hair pigmentation
- abnormal cranium morphology
- abnormal digit morphology
- abnormal eye morphology
- abnormal femur morphology
- abnormal head morphology
- abnormal heart left ventricle morphology
- abnormal heart morphology
- abnormal hindlimb morphology
- abnormal joint morphology
- abnormal lens morphology
- abnormal maxilla morphology
- abnormal motor capabilities/coordination/movement
- abnormal nail morphology
- abnormal optic disk morphology
- abnormal skin pigmentation
- abnormal spine curvature
- abnormal spleen morphology
- abnormal startle reflex
- abnormal stomach morphology
- abnormal tail length
- abnormal tail morphology
- abnormal tail movements
- abnormal tibia morphology
- abnormal vertebrae morphology
- abnormal vocalization
- aorta stenosis
- brachydactyly
- cataract
- decreased body length
- decreased body weight
- decreased bone mineral content
- decreased bone mineral density
- decreased cardiac stroke volume
- decreased circulating free fatty acid level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased fasting circulating glucose level
- decreased grip strength
- decreased hematocrit
- decreased hemoglobin content
- decreased lean body mass
- decreased leukocyte cell number
- decreased spleen weight
- decreased startle reflex
- decreased total body fat amount
- enlarged heart
- eye hemorrhage
- fusion of vertebral arches
- hydrometra
- hypoactivity
- increased blood urea nitrogen level
- increased body length
- increased circulating HDL cholesterol level
- increased circulating amylase level
- increased circulating calcium level
- increased fasting circulating glucose level
- increased heart rate
- increased lean body mass
- increased prepulse inhibition
- increased total body fat amount
- lipid deposition
- persistence of hyaloid vascular system
- preweaning lethality incomplete penetrance
- short tibia
- shortened RR interval
- small superior vagus ganglion
- vertebral fusion
- abnormal RR interval
- abnormal adipose tissue amount
- abnormal body length
- abnormal bone mineralization
- abnormal cell nucleus morphology
- abnormal circulating amylase level
- abnormal fasting circulating glucose level
- abnormal grip strength
- abnormal hair shaft morphology
- abnormal lean body mass
- abnormal locomotor activation
- abnormal prepulse inhibition
- fused joints
- increased bone mineral density
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnase1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- corneocyte development
- DNA catabolic process
- hair follicle development
- DNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- DNA binding
- deoxyribonuclease activity
- calcium ion binding
- deoxyribonuclease I activity