Cd55 Gene Summary [Rat]
Enables enzyme inhibitor activity. Involved in several processes, including maternal process involved in parturition; negative regulation of complement activation; and response to peptide hormone. Located in apical plasma membrane. Used to study neuroblastoma and proteinuria. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd55 |
| Official Name | CD55 molecule (Cromer blood group) [Source:RGD Symbol;Acc:620651] |
| Ensembl ID | ENSRNOG00000003927 |
| Bio databases IDs | |
| Aliases | CD55 molecule (Cromer blood group) |
| Synonyms | CD55 molecule (Cromer blood group), CD55 molecule, decay accelerating factor for complement, CHAPLE, CR, CROM, DAF, Daf1, Daf a GPI, Daf/cd55, Daf-GPI, GPI-DAF, TC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd55 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- lipid binding
- viral receptor
- STP box
- enzyme inhibitor activity
- serine threonine rich domain
- protein binding
- Sushi repeat (SCR repeat)
- glycosylphosphatidylinisitol attachment signal
- glycosylphosphatidylinositol anchor sequence
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Cd55 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reperfusion injury
- sepsis
- squamous cell cancer
- non-small cell lung cancer
- myocardial infarction
- pervasive developmental disorder
- systemic lupus erythematosus
- proteinuria
- glomerulosclerosis
- infection
role in cell
- survival
- apoptosis
- activation in
- proliferation
- growth
- adhesion
- activation
- deposition in
- expansion
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- detergent-insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- Extracellular Space
- microvesicles
- membrane surface
- cellular membrane
- vesicles
- secretory granule membrane
- apical cell surfaces
- basolateral cell surfaces
- plasma membrane extracellular face
- apical membrane
- caveolae
- Golgi membrane
- sperm midpiece
- sarcolemma
- transport vesicles
- extracellular matrix
- membrane rafts
- exosomes
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd55 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- negative regulation of complement activation
- regulation of complement activation
- complement activation, classical pathway
- innate immune response
- positive regulation of CD4-positive, alpha-beta T cell activation
- positive regulation of T cell cytokine production
- respiratory burst
- regulation of lipopolysaccharide-mediated signaling pathway
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- membrane raft
- Golgi membrane
- transport vesicle
- extracellular region
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid binding
- viral receptor activity