Impad1 Gene Summary [Rat]
Predicted to enable 3',5'-nucleotide bisphosphate phosphatase activity and 3'-nucleotidase activity. Predicted to be involved in skeletal system development. Predicted to act upstream of or within embryonic digit morphogenesis; post-embryonic development; and skeletal system development. Predicted to be located in cytosol; nuclear body; and trans-Golgi network membrane. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Impad1 |
| Official Name | inositol monophosphatase domain containing 1 [Source:RGD Symbol;Acc:1306455] |
| Ensembl ID | ENSRNOG00000046647 |
| Bio databases IDs | |
| Aliases | inositol monophosphatase domain containing 1 |
| Synonyms | 1110001C20Rik, 3'(2'), 5'-bisphosphate nucleotidase 2, B230207P20, GPAPP, IMP-3, IMPA3, IMPAD1, IMPase 3, Jaws, RGD1306455 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Impad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-nucleotidase
- phosphatase
- inositol-1(or 4)-monophosphatase
- enzyme
- Inositol monophosphatase family
- FIG
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- alcoholism
- hypoplasia
- GPAPP type chondrodysplasia with joint dislocations
- organismal death
- cleft palate
role in cell
- expression in
- migration
- invasion by
- endochondral ossification by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi lumen
- Golgi Apparatus
- cytosol
- trans Golgi network
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Impad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- post-embryonic development
- endochondral ossification
- chondrocyte development
- phosphatidylinositol phosphorylation
- chondroitin sulfate metabolic process
- embryonic digit morphogenesis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- membrane
- cytosol
- endomembrane system
- Golgi apparatus
- Golgi lumen
- trans-Golgi network membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'(2'),5'-bisphosphate nucleotidase activity
- 3'-nucleotidase activity
- metal ion binding