Mmp24 Gene Summary [Rat]
Predicted to enable cadherin binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; collagen catabolic process; and detection of temperature stimulus involved in sensory perception of pain. Predicted to be located in trans-Golgi network membrane. Predicted to be active in extracellular space and plasma membrane. Orthologous to human MMP24 (matrix metallopeptidase 24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp24 |
| Official Name | matrix metallopeptidase 24 [Source:RGD Symbol;Acc:620202] |
| Ensembl ID | ENSRNOG00000047028 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 24 |
| Synonyms | matrix metallopeptidase 24, MMP-21, MMP25, MT5-MMP, MT-MMP 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- Matrixin
- hemopexin domain
- catalytic domain
- peptidase
- HX
- Domain of unknown function (DUF3377)
- Zinc-dependent metalloprotease
- enzyme activator activity
- Putative peptidoglycan binding domain
- ZnMc
- cadherin binding
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp24 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- inflammatory hyperalgesia
- melanoma cancer
- endometriosis
- touch abnormality
- lung cancer
- organismal death
- breast cancer
- gastric cancer
- osteoarthritis
role in cell
- growth
- invasion by
- number
- differentiation
- degranulation
- shedding in
- outgrowth
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- apical cell surfaces
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell adhesion mediated by cadherin
- proteolysis
- extracellular matrix organization
- collagen catabolic process
- neuronal stem cell maintenance
- glial cell differentiation
- detection of temperature stimulus involved in sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- trans-Golgi network membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- cadherin binding
- enzyme activator activity
- metalloendopeptidase activity