Myot Gene Summary [Rat]
Predicted to enable alpha-actinin binding activity and cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in Z disc. Predicted to be active in axon and plasma membrane. Human ortholog(s) of this gene implicated in muscular dystrophy and myofibrillar myopathy 3. Orthologous to human MYOT (myotilin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myot |
| Official Name | myotilin [Source:RGD Symbol;Acc:1310569] |
| Ensembl ID | ENSRNOG00000047186 |
| Bio databases IDs | |
| Aliases | myotilin |
| Synonyms | 5530402I04Rik, LGMD1, LGMD1A, LOC100909761, MFM3, myotilin, TTID, TTOD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myot often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of muscle
- immunoglobulin domain
- actinin binding
- Penicillin-Binding Protein C-terminus Family
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- actin filaments
- sarcolemma
- Z line
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myot gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse organization
- muscle contraction
- axon guidance
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- Z disc
- sarcolemma
- actin cytoskeleton
- neuronal cell body
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- actin binding
- alpha-actinin binding
- axon guidance receptor activity