Ccs Gene Summary [Rat]
Enables enzyme binding activity. Predicted to be involved in removal of superoxide radicals. Predicted to act upstream of or within positive regulation of oxidoreductase activity. Predicted to be located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human CCS (copper chaperone for superoxide dismutase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccs |
| Official Name | copper chaperone for superoxide dismutase [Source:RGD Symbol;Acc:620403] |
| Ensembl ID | ENSRNOG00000047816 |
| Bio databases IDs | |
| Aliases | copper chaperone for superoxide dismutase |
| Synonyms | Ccsd, Copper Chaperone For Superoxide Dismutase, LOC100911589 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- Heavy-metal-associated domain
- copper ion binding protein
- protein disulfide oxidoreductase
- enzyme binding
- enzyme
- protein binding
- Copper/zinc superoxide dismutase (SODC)
- HMA
- superoxide dismutase copper chaperone
- Cu-Zn_Superoxide_Dismutase
Pathways
Biological processes and signaling networks where the Ccs gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- lung adenocarcinoma
- lung adenocarcinoma formation
- amyotrophic lateral sclerosis
role in cell
- apoptosis
- proliferation
- response by
- aggregation in
- autophagy in
- maturation in
- palmitoylation in
- sensitivity
- disulfide bonding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial intermembrane space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- superoxide metabolic process
- removal of superoxide radicals
- intracellular copper ion transport
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide oxidoreductase activity
- copper ion binding
- cadherin binding
- superoxide dismutase copper chaperone activity