Pspn Gene Summary [Rat]
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | Pspn |
| Official Name | persephin [Source:RGD Symbol;Acc:3432] |
| Ensembl ID | ENSRNOG00000049171 |
| Bio databases IDs | |
| Aliases | persephin |
| Synonyms | persephin, PSP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pspn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- Transforming growth factor beta like domain
- receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Pspn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pspn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glial cell-derived neurotrophic factor receptor signaling pathway
- central nervous system development
- nervous system development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- receptor binding
- receptor tyrosine kinase binding
- glial cell line-derived neurotrophic factor receptor binding