Cbx2 Gene Summary [Rat]
Predicted to enable chromatin binding activity; histone H3K9me2/3 reader activity; and methylated histone binding activity. Predicted to be involved in development of primary sexual characteristics and negative regulation of transcription by RNA polymerase II. Predicted to be located in euchromatin and nucleoplasm. Predicted to be part of PRC1 complex. Predicted to be active in heterochromatin. Human ortholog(s) of this gene implicated in 46,XY sex reversal 5. Orthologous to human CBX2 (chromobox 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbx2 |
| Official Name | chromobox 2 [Source:RGD Symbol;Acc:1588561] |
| Ensembl ID | ENSRNOG00000049215 |
| Bio databases IDs | |
| Aliases | chromobox 2 |
| Synonyms | CDCA6, chromobox 2, HPC1, M33, MGC10561, MOD2, MODIFIER3, pc, PC1, SRXY5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cbx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polycomb conserved domain
- Chromatin organization modifier domain
- CBX family C-terminal motif
- transcription regulator
- transcription repression domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- Ring1 binding domain
- protein binding activity, bridging
- chromatin binding
- protein binding
- Chromo (CHRromatin organization MOdifier) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- breast carcinoma
- metastasis
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- lung squamous cell carcinoma
- squamous cell lung cancer
- immunodeficiency
role in cell
- expression in
- migration
- growth
- proliferation
- phosphorylation in
- apoptosis
- invasion
- accumulation in
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cbx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- development of primary sexual characteristics
- cell differentiation
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- euchromatin
- PRC1 complex
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- methylated histone residue binding
- chromatin binding