Ppp2r3b Gene Summary [Rat]
Predicted to enable calcium-dependent protein serine/threonine phosphatase activity; chromatin binding activity; and protein phosphatase regulator activity. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be located in cilium; cytosol; and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp2r3b |
| Official Name | protein phosphatase 2, regulatory subunit B'', beta [Source:RGD Symbol;Acc:1588134] |
| Ensembl ID | ENSRNOG00000049270 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2, regulatory subunit B'', beta |
| Synonyms | CAAA01125382.1, LOC108167320, LOC108167694, PP2A B''-PR59, PP2A PR59, Ppp2r3, Ppp2r3a, Ppp2r3b, PR59, protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta, protein phosphatase 2 (formerly 2A), regulatory subunit B'', δ, protein phosphatase 2, regulatory subunit B'', beta, protein phosphatase 2, regulatory subunit B'', β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp2r3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine/threonine protein phosphatase 2A regulatory subunit B''
- EF-hand domain
- calcium-dependent protein serine/threonine phosphatase
- EF-hand domain pair
- EF hand
- phosphatase
- protein phosphatase regulator
- chromatin binding
- protein binding
Pathways
Biological processes and signaling networks where the Ppp2r3b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- Autophagy
- Breast Cancer Regulation by Stathmin1
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- WNT/β-catenin Signaling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- cytosol
- nucleoplasm