Nlrp2 Gene Summary [Rat]
Predicted to enable Pyrin domain binding activity. Predicted to be involved in negative regulation of non-canonical NF-kappaB signal transduction; positive regulation of interleukin-1 beta production; and regulation of inflammatory response. Predicted to be located in Golgi apparatus; chromosome, telomeric region; and cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to several human genes including NLRP2 (NLR family pyrin domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp2 |
| Official Name | NLR family pyrin domain containing 2 [Source:RGD Symbol;Acc:1589140] |
| Ensembl ID | ENSRNOG00000049759 |
| Bio databases IDs | |
| Aliases | NLR family pyrin domain containing 2 |
| Synonyms | CLR19.9, LOC684545, NALP2, NBS1, NLR family pyrin domain containing 2, OZEMA18, PAN1, PYPAF2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nlrp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- NOD2 winged helix domain
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- linker domain
- protein domain specific binding
- protein binding
- NACHT domain
- AAA domain
- leucine-rich repeat
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Nlrp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- venous thromboembolism
- primary Sjögren syndrome
- oocyte/zygote/embryo maturation arrest 18
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- diabetic nephropathy
- multisystem inflammatory syndrome in children
role in cell
- phosphorylation in
- disassembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
- cytosol
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nlrp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- innate immune response
- apoptotic process
- regulation of inflammatory response
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- Pyrin domain binding