Smc1a Gene Summary [Rat]
Predicted to enable several functions, including chromatin binding activity; mediator complex binding activity; and protein heterodimerization activity. Involved in meiotic cell cycle. Located in lateral element and nucleoplasm. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to human SMC1A (structural maintenance of chromosomes 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smc1a |
| Official Name | structural maintenance of chromosomes 1A [Source:RGD Symbol;Acc:61991] |
| Ensembl ID | ENSRNOG00000003139 |
| Bio databases IDs | |
| Aliases | structural maintenance of chromosomes 1A |
| Synonyms | 5830426I24Rik, CDLS2, DEE85, DXS423E, EIEE85, mKIAA0178, SB1.8, SMC1, SMC1alpha, SMC1 beta, SMC1L1, Smc1 α, SMC1 β, SMCB, STRUCTURAL MAINTENANCE of CHROMOSOMES 1, structural maintenance of chromosomes 1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smc1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, primarily archaeal type
- SMC proteins Flexible Hinge Domain
- exonuclease SbcC
- binding protein
- chromatin binding
- enzyme
- protein binding
- protein heterodimerization
- phosphorylation site
- AAA domain
Pathways
Biological processes and signaling networks where the Smc1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- Cornelia de Lange syndrome type 2
- lung squamous cell carcinoma
- squamous cell lung cancer
- X-linked complex neurodevelopmental disorder
- Wiedemann-Steiner syndrome
- hereditary disorder
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- expression in
- proliferation
- number
- migration
- cell death
- survival
- quantity
- invasion by
- assembly
- metaphase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule aster fraction
- Cytoplasm
- cytosol
- connecting cilia
- chromosome
- nuclear pores
- nucleoplasm
- nucleoli
- spindle pole
- nuclear matrix
- kinetochores
- centromeres
- synaptonemal complexes
- chromatin
- chromosomal axial elements
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smc1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- DNA repair
- establishment of meiotic sister chromatid cohesion
- mitotic sister chromatid cohesion
- establishment of mitotic sister chromatid cohesion
- response to radiation
- cell division
- meiotic cell cycle
- mitotic sister chromatid segregation
- somatic stem cell maintenance
- response to DNA damage checkpoint signal
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear matrix
- cytosol
- meiotic cohesin complex
- cohesin complex
- mitotic cohesin complex
- chromosome
- kinetochore
- chromosome, centromeric region
- nucleoplasm
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- RNA binding
- protein binding
- protein heterodimerization activity
- mediator complex binding
- chromatin binding