Gcnt1 Gene Summary [Rat]
This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Gcnt1 |
| Official Name | glucosaminyl (N-acetyl) transferase 1 [Source:RGD Symbol;Acc:621370] |
| Ensembl ID | ENSRNOG00000050534 |
| Bio databases IDs | |
| Aliases | glucosaminyl (N-acetyl) transferase 1 |
| Synonyms | 5630400D21Rik, B130048E03, beta-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE, C2 GlcNAcT, C2GNT, C2GNT1, C2GNT-L, core 2 GlcNAc-T, core 2 β 1,6 n acetylglucosaminyltransferase leukocyte type, G6NT, glucosaminyl (N-acetyl) transferase 1, glucosaminyl (N-acetyl) transferase 1, core 2, IGnT, LOC635918, NACGT2, NAGCT2, β-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gcnt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Core-2/I-Branching enzyme
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- delayed hypersensitive reaction
- preeclampsia
role in cell
- binding in
- cell death
- proliferation
- quantity
- differentiation
- number
- binding
- abnormal morphology
- cell rolling
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- medial face of the Golgi apparatus
- cis face of the Golgi apparatus
- Golgi membrane
- trans Golgi network
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gcnt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion molecule production
- tissue morphogenesis
- response to insulin stimulus
- kidney morphogenesis
- glycoprotein biosynthetic process
- leukocyte tethering or rolling
- O-glycan processing
- O-glycan processing, core 2
Cellular Component
Where in the cell the gene product is active
- extracellular space
- trans-Golgi network
- membrane
- Golgi membrane
- Golgi cisterna
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity