Klrc1 Gene Summary [Rat]
Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity and MHC class I protein complex binding activity. Predicted to be involved in CD8-positive, gamma-delta intraepithelial T cell differentiation; immune response-regulating cell surface receptor signaling pathway; and regulation of leukocyte mediated cytotoxicity. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klrc1 |
| Official Name | killer cell lectin like receptor C1 [Source:RGD Symbol;Acc:2976] |
| Ensembl ID | ENSRNOG00000055196 |
| Bio databases IDs | |
| Aliases | killer cell lectin like receptor C1 |
| Synonyms | CD159A, killer cell lectin like receptor C1, NKG2, NKG2A, rNKG2A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klrc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- binding protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- immunoreceptor tyrosine-based inhibition motif
- ectodomain
- Lectin C-type domain
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Klrc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic squamous cell carcinoma of the oral cavity
- recurrent laryngeal squamous cell carcinoma
- oropharyngeal squamous-cell carcinoma
- metastatic squamous cell carcinoma of the hypopharynx
- oral squamous cell carcinoma
- psoriasis
- Tourette syndrome
- hypopharyngeal squamous cell carcinoma
- metastatic oropharyngeal squamous cell carcinoma
- metastatic squamous cell carcinoma of the larynx
role in cell
- cell death
- killing
- activation
- cytotoxicity
- cell spreading
- exclusion
- stimulation
- induction
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klrc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of natural killer cell activation
- CD8-positive, gamma-delta intraepithelial T cell differentiation
- innate immune response
- natural killer cell inhibitory signaling pathway
- adaptive immune response
- negative regulation of T cell mediated cytotoxicity
- cell surface receptor signaling pathway
- negative regulation of natural killer cell mediated cytotoxicity
- positive regulation of natural killer cell mediated cytotoxicity
- stimulatory C-type lectin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- protein binding
- transmembrane signaling receptor activity
- carbohydrate binding