Arhgef10l Gene Summary [Rat]
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in SREBP signaling pathway; actin cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to human ARHGEF10L (Rho guanine nucleotide exchange factor 10 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef10l |
| Official Name | Rho guanine nucleotide exchange factor 10 like [Source:RGD Symbol;Acc:1585585] |
| Ensembl ID | ENSRNOG00000050636 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 10 like |
| Synonyms | 2810441C07Rik, GrinchGEF, LOC108351053, Rho guanine nucleotide exchange factor 10-like |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef10l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- WD40 repeated domain
- PH domain
- GTPase activator
- enzyme
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Arhgef10l gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- insomnia
- cortical visual impairment and intellectual disability
- lung adenocarcinoma
- lung adenocarcinoma formation
- major depression
- neuroticism
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef10l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SREBP-mediated signaling pathway
- regulation of small GTPase mediated signal transduction
- positive regulation of stress fiber assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity
- GTPase activator activity