Dnmbp Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cilium assembly and regulation of cell shape. Located in Golgi apparatus and presynapse. Is active in synaptic vesicle. Human ortholog(s) of this gene implicated in cataract 48. Orthologous to human DNMBP (dynamin binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnmbp |
| Official Name | dynamin binding protein [Source:RGD Symbol;Acc:1583840] |
| Ensembl ID | ENSRNOG00000050742 |
| Bio databases IDs | |
| Aliases | dynamin binding protein |
| Synonyms | 2410003L07Rik, 2410003M15Rik, ARHGEF36, CTRCT48, dynamin binding protein, KIAA1010, LOC101927371, TUBA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnmbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- protein binding
- BAR domain
- Bin/Amphiphysin/Rvs domain
- Dbl homology domain
- RhoGEF domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- Golgi Apparatus
- intercellular junctions
- cytosol
- Golgi stacks
- nucleoplasm
- nucleoli
- nuclear bodies
- synaptic vesicles
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnmbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cilium morphogenesis
- regulation of small GTPase mediated signal transduction
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoskeleton
- cytoplasm
- cytosol
- Golgi apparatus
- synapse
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity