Slc48a1 Gene Summary [Rat]
Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in several processes, including heme transport; localization of cell; and phagocytosis. Predicted to be located in endolysosome and endosome membrane. Predicted to be active in phagolysosome membrane and plasma membrane. Orthologous to human SLC48A1 (solute carrier family 48 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc48a1 |
| Official Name | solute carrier family 48 member 1 [Source:RGD Symbol;Acc:1562880] |
| Ensembl ID | ENSRNOG00000053196 |
| Bio databases IDs | |
| Aliases | solute carrier family 48 member 1 |
| Synonyms | 4930570C03Rik, FLJ20489, hHRG-1, HRG, HRG-1, solute carrier family 48 (heme transporter), member 1, solute carrier family 48 member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc48a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haem-transporter, endosomal/lysosomal, haem-responsive gene
- protein binding
- heme binding
- heme transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc48a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal adenoma
- colorectal adenoma formation
- cervical cancer
regulated by
- heme
- BACH1
- diethylnitrosamine
- dexamethasone
- quercetin
- phenobarbital
role in cell
- expression in
- cell viability
- phosphorylation in
- migration
- invasion by
- internalization by
- phagocytosis by
- pH
- production in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- lysosome membrane
- endosomal membrane
- recycling endosomes
- early endosomes
- late endosomes
- endolysosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc48a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- localization of cell
- heme export
- lysosomal transport
- phagocytosis
- heme metabolic process
- heme transport
Cellular Component
Where in the cell the gene product is active
- endosome membrane
- plasma membrane
- lysosomal membrane
- endolysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- heme transporter activity
- heme binding