SLC48A1 Gene Summary [Human]
Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in endosome membrane; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC48A1 |
| Official Name | solute carrier family 48 member 1 [Source:HGNC Symbol;Acc:HGNC:26035] |
| Ensembl ID | ENSG00000211584 |
| Bio databases IDs | |
| Aliases | solute carrier family 48 member 1 |
| Synonyms | 4930570C03Rik, FLJ20489, hHRG-1, HRG, HRG-1, solute carrier family 48 (heme transporter), member 1, solute carrier family 48 member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC48A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haem-transporter, endosomal/lysosomal, haem-responsive gene
- protein binding
- heme binding
- heme transporter
- transporter
Pathways
Biological processes and signaling networks where the SLC48A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- lysosome membrane
- endosomal membrane
- recycling endosomes
- early endosomes
- late endosomes
- endolysosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC48A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- localization of cell
- heme export
- lysosomal transport
- phagocytosis
- heme metabolic process
- heme transport
Cellular Component
Where in the cell the gene product is active
- endosome membrane
- plasma membrane
- lysosomal membrane
- endolysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- heme transporter activity
- heme binding