Cfi Gene Summary [Rat]
Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Involved in cellular response to interleukin-6. Located in extracellular space. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfi |
| Official Name | complement factor I [Source:RGD Symbol;Acc:620429] |
| Ensembl ID | ENSRNOG00000053400 |
| Bio databases IDs | |
| Aliases | complement factor I |
| Synonyms | AHUS3, ARMD13, C3BINA, complement component factor i, complement factor I, Factor I, FI, IF, I factor (complement), KAF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cfi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- Trypsin-like serine protease
- Tryp_SPc
- factor I membrane attack complex
- peptidase
- protein binding
- KAZAL_FS
- Scavenger receptor Cys-rich
- trypsin
- serine endopeptidase
- complement factor I
- LDLa
- Trypsin-like peptidase domain
Pathways
Biological processes and signaling networks where the Cfi gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- atypical hemolytic uremic syndrome
- COVID-19
- susceptibility to atypical hemolytic uremic syndrome type 3
- macular degeneration
- early-onset preeclampsia
- organismal death
- factor I deficiency
- retinopathy
- age-related macular degeneration
role in cell
- production in
- molecular cleavage in
- cytolysis
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cfi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, classical pathway
- innate immune response
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- serine-type endopeptidase activity