Fgf6 Gene Summary [Rat]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Fgf6 |
| Official Name | fibroblast growth factor 6 [Source:RGD Symbol;Acc:620130] |
| Ensembl ID | ENSRNOG00000053662 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 6 |
| Synonyms | Fgf7b, fibroblast growth factor 6, HBGF-6, HST2, HSTF-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- fibrosis
- hemochromatosis
- colorectal cancer
- systemic sclerosis
- rotator cuff injury
role in cell
- activation
- number
- proliferation
- expression in
- survival
- migration
- cell death
- phosphorylation in
- outgrowth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- myoblast differentiation
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- organ morphogenesis
- cartilage condensation
- positive regulation of cell division
- angiogenesis
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- sarcolemma
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding