Fgf6 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within cartilage condensation and myoblast differentiation. Predicted to be located in sarcolemma. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and skeletal musculature. Orthologous to human FGF6 (fibroblast growth factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf6 |
| Official Name | fibroblast growth factor 6 [Source:MGI Symbol;Acc:MGI:95520] |
| Ensembl ID | ENSMUSG00000000183 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 6 |
| Synonyms | Fgf7b, fibroblast growth factor 6, HBGF-6, HST2, HSTF-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- fibrosis
- hemochromatosis
- colorectal cancer
- systemic sclerosis
- rotator cuff injury
role in cell
- activation
- number
- proliferation
- expression in
- survival
- migration
- cell death
- phosphorylation in
- outgrowth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- myoblast differentiation
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- organ morphogenesis
- cartilage condensation
- positive regulation of cell division
- angiogenesis
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- sarcolemma
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding