Cldn2 Gene Summary [Rat]
Predicted to enable identical protein binding activity and paracellular tight junction channel activity. Predicted to be involved in several processes, including bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and regulation of intestinal absorption. Predicted to be located in nucleoplasm and tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN2 (claudin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn2 |
| Official Name | claudin 2 [Source:RGD Symbol;Acc:1560247] |
| Ensembl ID | ENSRNOG00000054495 |
| Bio databases IDs | |
| Aliases | claudin 2 |
| Synonyms | Claudin-2, OAZON, RGD1560247 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein binding
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the Cldn2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypercalciuria
- colon adenocarcinoma
- colon epithelial cancer
- colon cancer
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
- hypoxia
- reperfusion injury
- obstructive azoospermia with nephrolithiasis
- hepatocellular carcinoma
role in cell
- proliferation
- expression in
- activation in
- growth
- sphere formation
- transepithelial electrical resistance
- formation
- internalization by
- binding
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- cell junction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell borders
- apical compartment
- cellular membrane
- Nucleus
- intercellular junctions
- cell-cell contacts
- tight junctional strands
- apical membrane
- nucleoplasm
- nodes of Ranvier
- Schmidt-Lanterman incisures
- tight junctions
- junctional complexes
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-cell adhesion
- transmembrane transport
- tight junction assembly
Cellular Component
Where in the cell the gene product is active
- tight junction
- cell-cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- channel activity
- identical protein binding
- protein binding
- structural molecule activity