Tfb1m Gene Summary [Rat]
Predicted to enable S-adenosyl-L-methionine binding activity; mitochondrial transcription factor activity; and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human TFB1M (transcription factor B1, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfb1m |
| Official Name | transcription factor B1, mitochondrial [Source:RGD Symbol;Acc:727795] |
| Ensembl ID | ENSRNOG00000056223 |
| Bio databases IDs | |
| Aliases | transcription factor B1, mitochondrial |
| Synonyms | CGI-75, mtTFB, mtTFB1, transcription factor B1, mitochondrial |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tfb1m often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ribosomal RNA small subunit methyltransferase A
- binding protein
- rRNA (adenine-N6,N6-)-dimethyltransferase
- Ribosomal RNA adenine dimethylase
- RNA methyltransferase domain
- protein binding
- AdoMet_MTases
Pathways
Biological processes and signaling networks where the Tfb1m gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- progressive hearing impairment
regulates
- TFB1M
- E2F1
- mitochondrial DNA
- MT-RNR1
role in cell
- expression in
- apoptosis
- function
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tfb1m gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription initiation from mitochondrial promoter
- rRNA modification
- rRNA methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- mitochondrial RNA polymerase binding promoter specificity activity
- rRNA (adenine-N6,N6-)-dimethyltransferase activity