Dnaaf4 Gene Summary [Rat]
Enables nuclear estrogen receptor binding activity. Involved in neuron migration. Located in centrosome; cytoplasm; and non-motile cilium. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnaaf4 |
| Official Name | dynein axonemal assembly factor 4 [Source:RGD Symbol;Acc:1549760] |
| Ensembl ID | ENSRNOG00000056654 |
| Bio databases IDs | |
| Aliases | dynein axonemal assembly factor 4 |
| Synonyms | 1700010I24RIK, b2b811.1Clo, b2b811Clo, CILD25, dynein axonemal assembly factor 4, DYX1, DYX1C1, DYXC1, Edem2, EKN1, pf23, RD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnaaf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- TPR repeat
- alpha-crystallin Hsps/p23-like
- Tetratricopeptide repeats
- protein binding
- estrogen receptor binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary ciliary dyskinesia
- primary ciliary dyskinesia type 25
- dextrocardia
- congenital heart disease
- susceptibility to dyslexia type 1
- hydrocephalus
- situs inversus
- situs inversus totalis
- situs ambiguus
- hearing loss
regulates
- Axonemal Dynein Inner Arm
- Axonemal Dynein Outer Arm
role in cell
- migration
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- non-motile cilium
- organelle
- Cytoplasm
- cilia
- Plasma Membrane
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnaaf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- neuron migration
- regulation of proteasomal protein catabolic process
- outer dynein arm assembly
- epithelial cilium movement
- regulation of intracellular estrogen receptor signaling pathway
- cilium movement
- establishment of localization in cell
- inner dynein arm assembly
- determination of left/right symmetry
- learning or memory
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- extracellular region
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- estrogen receptor binding