Chrna9 Gene Summary [Rat]
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in negative regulation of ERK1 and ERK2 cascade. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in lung small cell carcinoma. Orthologous to human CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrna9 |
| Official Name | cholinergic receptor nicotinic alpha 9 subunit [Source:RGD Symbol;Acc:621534] |
| Ensembl ID | ENSRNOG00000002484 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic alpha 9 subunit |
| Synonyms | 2410015I05Rik, Acra9, cholinergic receptor nicotinic alpha 9 subunit, cholinergic receptor, nicotinic, alpha polypeptide 9, cholinergic receptor nicotinic α 9 subunit, cholinergic receptor, nicotinic, α polypeptide 9, EG666827, Gm8311, HSA243342, NACHRA9, Nachr α 9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrna9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- LGIC_ECD
- neurotransmitter receptor
- Neurotransmitter-gated ion-channel transmembrane region
- channel/pore class transporter
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- protein binding
- extracellular ligand-gated ion channel
- Cation transporter family protein
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrna9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postoperative pain
- COVID-19
- Alzheimer disease
- HIV infection
- morbid obesity
- hemodynamic instability
- insomnia
- psychological disorder
- neoplastic cell transformation
- acute respiratory distress syndrome
role in cell
- proliferation
- number
- phosphorylation in
- depolarization
- innervation
- function
- loss
- infiltration by
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synaptic membrane
- synaptic vesicles
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrna9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- ion transmembrane transport
- inner ear morphogenesis
- calcium ion transmembrane transport
- response to auditory stimulus
- synaptic transmission
- membrane depolarization
- detection of mechanical stimulus involved in sensory perception of sound
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- synapse
- acetylcholine-gated channel complex
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- acetylcholine-gated cation channel activity
- calcium channel activity