Cd300a Gene Summary [Rat]
Predicted to enable phosphatase binding activity; phospholipid binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including negative regulation of leukocyte activation; negative regulation of phagocytosis, engulfment; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of secretion by cell; receptor-mediated endocytosis; and serotonin secretion by mast cell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human CD300A (CD300a molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd300a |
| Official Name | Cd300a molecule [Source:RGD Symbol;Acc:1583719] |
| Ensembl ID | ENSRNOG00000057058 |
| Bio databases IDs | |
| Aliases | Cd300a molecule |
| Synonyms | B230315M08RIK, CD300A molecule, CLM-8, CMRF-35H, CMRF-35-H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60, LMIR1, MAIR-1, MAIR-I, MAIR-Ia, mcpir1, MMAC8, Pigr4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd300a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SHP2-interacting transmembrane adaptor protein, SIT
- extracellular domain
- phospholipid binding
- signaling receptor activity
- binding protein
- immunoglobulin domain
- phosphatidylethanolamine binding
- Immunoglobulin like
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- passive cutaneous anaphylaxis
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
role in cell
- proliferation
- number
- degranulation
- activity
- activation
- survival
- cytotoxicity
- differentiation
- function
- transendothelial migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd300a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phagocytosis, engulfment
- negative regulation of MAP kinase activity
- cell adhesion
- negative regulation of mast cell degranulation
- immune system process
- negative regulation of eosinophil migration
- negative regulation of NK T cell activation
- negative regulation of B cell proliferation
- positive regulation of phosphoprotein phosphatase activity
- negative regulation of fibroblast proliferation
- negative regulation of B cell receptor signaling pathway
- regulation of T cell receptor signaling pathway
- negative regulation of MyD88-dependent toll-like receptor signaling pathway
- negative regulation of mast cell activation involved in immune response
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- tertiary granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- phosphatidylethanolamine binding
- protein binding
- transmembrane signaling receptor activity
- signaling receptor activity