CD300A Gene Summary [Human]
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | CD300A |
| Official Name | CD300a molecule [Source:HGNC Symbol;Acc:HGNC:19319] |
| Ensembl ID | ENSG00000167851 |
| Bio databases IDs | |
| Aliases | CD300a molecule |
| Synonyms | B230315M08RIK, CD300A molecule, CLM-8, CMRF-35H, CMRF-35-H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60, LMIR1, MAIR-1, MAIR-I, MAIR-Ia, mcpir1, MMAC8, Pigr4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD300A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SHP2-interacting transmembrane adaptor protein, SIT
- extracellular domain
- phospholipid binding
- signaling receptor activity
- binding protein
- immunoglobulin domain
- phosphatidylethanolamine binding
- Immunoglobulin like
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- passive cutaneous anaphylaxis
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
role in cell
- proliferation
- number
- degranulation
- activity
- activation
- survival
- cytotoxicity
- differentiation
- function
- transendothelial migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD300A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phagocytosis, engulfment
- negative regulation of MAP kinase activity
- cell adhesion
- negative regulation of mast cell degranulation
- immune system process
- negative regulation of eosinophil migration
- negative regulation of NK T cell activation
- negative regulation of B cell proliferation
- positive regulation of phosphoprotein phosphatase activity
- negative regulation of fibroblast proliferation
- negative regulation of B cell receptor signaling pathway
- regulation of T cell receptor signaling pathway
- negative regulation of MyD88-dependent toll-like receptor signaling pathway
- negative regulation of mast cell activation involved in immune response
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- tertiary granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- phosphatidylethanolamine binding
- protein binding
- transmembrane signaling receptor activity
- signaling receptor activity