Has3 Gene Summary [Rat]
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | Has3 |
| Official Name | hyaluronan synthase 3 [Source:RGD Symbol;Acc:628656] |
| Ensembl ID | ENSRNOG00000059362 |
| Bio databases IDs | |
| Aliases | hyaluronan synthase 3 |
| Synonyms | hyaluronan synthase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Has3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl transferase family group 2
- hyaluronan synthase
- enzyme
- protein binding
- Glycosyltransferase like family 2
- identical protein binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- Vogt-Koyanagi-Harada disease
- Hutchinson-Gilford progeria syndrome
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- apoptosis
- proliferation
- expression in
- migration
- formation
- adhesion
- growth
- invasion
- density
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Nucleus
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Has3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- positive regulation of transcription, DNA-dependent
- extracellular polysaccharide biosynthetic process
- extracellular matrix assembly
- hyaluronan biosynthetic process
- positive regulation of hyaluranon cable assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- membrane
- Golgi membrane
- Golgi apparatus
- plasma membrane
- hyaluranon cable
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- hyaluronan synthase activity