B4galt1 Gene Summary [Rat]
Predicted to enable several functions, including UDP-galactosyltransferase activity; manganese ion binding activity; and tubulin binding activity. Predicted to be involved in lipid metabolic process; positive regulation of circulating fibrinogen levels; and protein N-linked glycosylation. Predicted to act upstream of or within several processes, including binding activity of sperm to zona pellucida; lactose biosynthetic process; and regulation of epithelial cell proliferation. Predicted to be located in several cellular components, including Golgi trans cisterna; basolateral plasma membrane; and brush border membrane. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | B4galt1 |
| Official Name | beta-1,4-galactosyltransferase 1 [Source:RGD Symbol;Acc:620900] |
| Ensembl ID | ENSRNOG00000059461 |
| Bio databases IDs | |
| Aliases | beta-1,4-galactosyltransferase 1 |
| Synonyms | 5B4GALT1, B-1,4-GalT, B-1,4-GalT1, beta-1,4-galactosyltransferase 1, beta-1,4-GalT, beta-1,4-GalT1, beta4Gal-T1, CDG2D, CLDLFIB, GalT, Ggtb, GGTB2, GT1, GTB, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, UDP-Gal:betaGlcNAc β 1,4- galactosyltransferase, polypeptide 1, β-1,4-galactosyltransferase 1, β-1,4-GalT, β-1,4-GalT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat B4galt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- G-protein regulatory motif
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
- N-terminal domain of galactosyltransferase
- enzyme
- N-acetyllactosamine synthase
- protein binding
- identical protein binding
- glycosyltransferase family A
- cytoplasmic domain
- galactosyltransferase
- transmembrane domain
- alpha-tubulin binding
- N-terminal region of glycosyl transferase group 7
- UDP-glycosyltransferase
- manganese ion binding
- lactose synthase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- neoplasia
- organismal death
- growth failure
- liver cancer
- hematuria
- hepatocellular carcinoma
- acute myeloid leukemia
- congenital disorder of glycosylation type 2d
role in cell
- proliferation
- apoptosis
- transactivation in
- activation
- expression in
- cell death
- chemotaxis
- adhesion
- migration
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- desmosomes
- cell-cell contacts
- secretory granule membrane
- plasma membrane extracellular face
- basolateral membrane
- Golgi membrane
- lysosome membrane
- nuclear envelope
- sperm head
- Golgi cisternae
- brush border
- cell membrane leading edge
- exosomes
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat B4galt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis involved in wound healing
- regulation of acrosome reaction
- penetration of zona pellucida
- positive regulation of epithelial cell proliferation involved in wound healing
- protein N-linked glycosylation
- oligosaccharide biosynthetic process
- cell adhesion
- epithelial cell development
- galactose metabolic process
- development of secondary sexual characteristics
- binding of sperm to zona pellucida
- lactose biosynthetic process
- epithelial cell proliferation
- acute inflammatory response
- lipid metabolic process
- positive regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- external side of plasma membrane
- Golgi membrane
- Golgi apparatus
- Golgi trans cisterna
- plasma membrane
- secretory granule membrane
- extracellular space
- brush border membrane
- extracellular vesicular exosome
- membrane
- filopodium
- desmosome
- macromolecular complex
- azurophil granule membrane
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
- UDP-galactosyltransferase activity
- N-acetyllactosamine synthase activity
- lactose synthase activity
- galactosyltransferase activity
- manganese ion binding
- cytoskeletal protein binding