St6gal1 Gene Summary [Rat]
Enables sialyltransferase activity. Involved in several processes, including negative regulation of macrophage apoptotic process; protein sialylation; and regulation of substrate adhesion-dependent cell spreading. Located in Golgi medial cisterna and Golgi trans cisterna. Used to study high grade glioma. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St6gal1 |
| Official Name | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 [Source:RGD Symbol;Acc:3676] |
| Ensembl ID | ENSRNOG00000001823 |
| Bio databases IDs | |
| Aliases | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
| Synonyms | beta galactoside alpha 2,6 sialyltransferase 1, CD75, CDw75, Gal Beta1,4-GlcNAc Alpha2,6-Sialyltransferase, HST6GAL 1, LOC102723861, N-GLYCAN-SPECIFIC alpha 2,6-SIALYLTRANSFERASE, N-GLYCAN-SPECIFIC α 2,6-SIALYLTRANSFERASE, Sialyltransferase 1, SIAT1, ST6 beta-galactoside alpha-2,6-sialyltransferase 1, St6gal, ST6GalI, ST6N, ST6 β-galactoside α-2,6-sialyltransferase 1, β galactoside α 2,6 sialyltransferase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat St6gal1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- beta-galactoside alpha-2,6-sialyltransferase
- glycosyltransferase family 29
- sialyltransferase
- protein homodimerization
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- severe acute respiratory syndrome
- diabetes mellitus
- IgA nephropathy
- gastric cancer
- ulcerative colitis
- non-insulin-dependent diabetes mellitus
- peripheral arterial disease
- hand-foot syndrome
- systemic lupus erythematosus
role in cell
- expression in
- damage in
- cell death
- growth
- quantity
- apoptosis
- binding
- production in
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- cell surface
- Extracellular Space
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- Golgi stacks
- trans Golgi network
- Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat St6gal1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mononuclear cell proliferation
- viral protein processing
- response to ethanol
- N-acetylneuraminate metabolic process
- humoral immune response
- regulation of substrate adhesion-dependent cell spreading
- negative regulation of chemotaxis
- protein N-linked glycosylation via asparagine
- O-glycan processing
- negative regulation of macrophage apoptotic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi apparatus
- Golgi membrane
- Golgi trans cisterna
- extracellular region
- Golgi medial cisterna
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- beta-galactoside alpha-2,6-sialyltransferase activity
- sialyltransferase activity