Target List
JAK & STAT Proteins
Janus Kinase Activity
Jak1, Jak2, Jak3, Tyk2
STAT Family Members
Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, Stat6
JAK / STAT Signaling Regulators
Pias1, Pias2, Prl, Ptpn1 (Ptp1b), Ptprc (Cd45), Sh2b2, Socs1, Socs2, Socs3, Socs4, Socs5
Receptors Binding & Activating JAK Proteins
Sh2b2, Csf1r, Cxcl9 (Mig), Egfr, Epor, Fas, Fcgr1, Ghr, Ifnar1, Ifngr1, Il10ra, Il10rb, Il2ra (Cd25), Il2rg, Il4ra (Cd124), Il6st (Gp130), Insr, Mpl (Tpor), Nr3c1 (GR), Pdgfra, Prlr, Ptprc (Cd45)
SH3 / SH2 Adaptor Protein Activity
Crk, Sh2b1, Src, Stam
STAT-Interacting Transcription Factors & Regulators
Transcription Factors
Cebpb, Gata3, Irf1, Jun, Junb, Myc, Nfkb1, Nr3c1 (GR), Spi1 (Sfpi1, PU1), Smad1, Smad2, Smad3, Smad4, Smad5, Sp1, Usf1
Transcriptional Regulation
Yy1
STAT-Induced
STAT1-Induced
Cxcl9 (Mig), Irf1, Nos2 (iNos)
STAT3-Induced
A2m, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Ccnd1, Cdkn1a (p21Cip1, Waf1), Cebpd, Crp, Fas, Irf1, Junb, Lrg1, Mcl1, Myc, Socs1, Socs3
STAT4-Induced
Fcgr1, Ifng, Irf1, Myc
STAT5-Induced
Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Ccnd1, Cdkn1a (p21Cip1, Waf1), Il2ra (Cd25), Irf1, Osm
STAT6-Induced
Fcer2a, Gata3, Il4, Il4ra (Cd124)
STAT1 / STAT2 / p48 Induced
Isg15, Oas1a
Apoptosis
Akt1, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Cdkn1a (p21Cip1, Waf1), Cebpb, Fas, Ifng, Il4, Jak2, Myc, Nfkb1, Prlr
Cell Growth and / or Maintenance
Cell Cycle
Ccnd1, Cdkn1a (p21Cip1, Waf1), Jun, Junb
Cell Proliferation
Il2ra (Cd25), Jak2, Myc, Ptprc (Cd45), Stat4, Stat6
Cell Growth
Egfr, Ifng, Il4, Osm, Pdgfra, Socs1, Socs2, Socs3, Socs4, Socs5
Cell Differentiation
Ccnd1, Cebpb, Gata3, Il20, Il4, Jak2, Jun, Nos2 (iNos), Prlr, Ptprc (Cd45), Spi1 (Sfpi1, PU1), Smad2, Socs2, Socs5, Stat3, Stat5a, Stat5b
Immune Response
Acute-Phase Response
Crp, F2 (Thrombin), Stat3
Inflammatory Response
Cebpb, Cxcl9 (Mig), Ifng, Il20, Il2ra (Cd25), Irf1, Nfkb1, Nos2 (iNos)
Lymphocyte Activation
Ifng, Il4, Prlr
Other Immune Response Genes
Isg15, Gbp2b, Il4ra (Cd124), Il6st (Gp130), Fas, Fcgr1, Irf9, Oas1a, Osm, Ptpn11, Stub1